Are Buzz Packs™ bad for the liver?

Buzz Packs deliver a microdose of THC and CBD in convenient powder form. Each stick pack dissolves in any beverage without the liver damage associated with alcohol.

Keep reading to see why our THC beverages are gentle on the liver and a healthier alternative to booze.

The effects of THC and CBD on the liver

Your liver processes tetrahydrocannabinol (THC) and cannabidiol (CBD) through the cytochrome P450 enzyme system. This group of enzymes breaks down drugs, toxins, and cannabinoids into compounds your body can more easily excrete. The metabolism affects how long cannabinoids remain active in your system.

The liver contains cannabinoid receptors CB1 and CB2, part of your body's endocannabinoid system (ECS). This complex network helps balance bodily functions from mood and appetite to inflammation and pain. In the liver specifically, these receptors help control metabolism and energy.

THC and CBD interact with these receptors to influence liver metabolism and inflammation. Here’s what happens when you consume cannabis:

• Your liver enzymes respond to dosage: High doses of THC (over 20 mg) can temporarily elevate liver enzymes such as ALT, AST, and ALP. This puts short-term strain on your liver, though these levels typically return to normal when you stop or reduce cannabis use. People with existing liver conditions often show more pronounced enzyme changes with high-dose cannabis.
• Cannabis affects fat metabolism in the liver: THC and CBD influence how your liver stores and processes fats. CBD activates PPAR-γ receptors that control fat metabolism, potentially reducing fat accumulation in liver cells. THC works differently depending on dosage: lower amounts primarily activate anti-inflammatory CB2 receptors, while higher doses more strongly stimulate CB1 receptors that can increase fat storage.
• Cannabinoids impact inflammation pathways: CBD and low-dose THC decrease proinflammatory cytokines that damage liver cells. This anti-inflammatory effect might help protect against liver damage from various sources. A 2024 study found CBD improved glucose tolerance and reduced inflammatory responses in non-alcoholic fatty liver disease models.
• Processing efficiency varies with dosage: High amounts of cannabis can overwhelm your liver's cytochrome P450 system. This affects how efficiently your body processes the cannabinoids and how they interact with other medications metabolized through the same pathway. Water-soluble cannabinoid formulations may be processed differently than oil-based products.

A 2023 study in the Canadian Liver Journal explains that cannabis compounds affect liver health based on dosage—small amounts offer potential benefits while large amounts could cause harm. 

This is why microdosing with Buzz Packs makes sense for liver health. You get all the therapeutic benefits of cannabis without the enzyme elevation that comes with higher doses. Our low-dose cannabis beverages are effective enough to make you feel the effects without putting unnecessary strain on your body.

What are the benefits of Buzz Packs for the liver?

Your liver processes everything you consume including cannabis. The good news? Our Buzz Packs actually support liver health rather than harm it because they contain therapeutic microdoses that don’t overwhelm your system. The carefully measured 5 mg THC and 5 mg CBD combination works with your body's natural systems to provide several benefits.

THC and CBD in Buzz Packs reduce inflammation

The cannabinoids in Buzz Packs activate CB2 receptors in liver tissues to fight inflammation. Recent studies show these anti-inflammatory properties may help protect against alcoholic liver disease and chronic hepatitis. When activated by THC and CBD in Buzz Packs, they suppress pro-inflammatory cytokines that damage liver cells. 

Buzz Packs offer protection against liver injury

Low-dose cannabinoids shield liver cells from oxidative damage. This antioxidant activity neutralizes free radicals before they can damage liver cell membranes and DNA. When your liver processes alcohol, medications, or environmental toxins, it generates harmful compounds that CBD helps neutralize. 

Buzz Packs alleviate stress 

Psychological stress worsens liver conditions by triggering inflammation and disrupting metabolism. Buzz Packs reduce anxiety without the intense high of larger THC doses. The THC microdose provides mild relaxation while CBD counteracts anxiety-inducing effects that can occur with higher THC doses. This lowers cortisol levels that, when chronically elevated, can damage liver function and increase fat deposition in liver cells. 

A 2019 review showed that low-dose cannabinoids improved stress biomarkers associated with non-alcoholic fatty liver disease, which suggests that Buzz Packs may help break the stress-liver damage cycle.

Buzz Packs have the upper edge over medications

Many pain relievers, like acetaminophen and NSAIDs, hurt your liver with regular use. Just 4,000 mg of acetaminophen daily can cause liver damage, while NSAIDs increase risk of liver failure by up to 9 times with extended use. 

Buzz Packs deliver effective pain relief without these toxic effects. The combined action of THC and CBD blocks pain signals through different mechanisms than conventional painkillers, bypassing liver-damaging pathways entirely. 

Buzz Packs improve metabolism

The 1:1 THC:CBD ratio in drinks made with Buzz Packs helps improve glucose regulation and fat metabolism in your liver. At this ratio, cannabis can increase insulin sensitivity and reduce fat accumulation in liver cells. This metabolic benefit is most effective at the low 5 mg dosage because higher doses can produce opposite effects. The water-soluble format in Buzz Packs increases bioavailability, so more of these beneficial compounds can reach your liver cells.

Experience minimal side effects with Buzz Packs

Unlike synthetic cannabinoids or high-dose products, Buzz Packs rarely cause side effects that might indirectly harm your liver. High-dose THC can increase heart rate and blood pressure, forcing your liver to work harder at processing stress hormones. 

The carefully calibrated dose in Buzz Packs avoids these cardiovascular effects while providing therapeutic benefits. Your liver doesn't have to process unknown metabolites from synthetic compounds, making the all-natural Buzz Packs a cleaner option for liver health.

We can’t think of a better way to reap those benefits than with a chilled glass of our blueberry thyme mocktail, a cannabis twist on the classic mojito, or any other mouth-watering mocktail from our recipe book. Add a Buzz Pack to your favorite drink, stir well until fully dissolved, and enjoy the liver-friendly effects of precisely dosed cannabinoids with every sip.

“Just started using the Buzz packs. They are not super strong, but one pack mixed in a glass of orange juice made for a smooth and calming nightcap. Don't drink alcohol anymore and this is a great alternative.”

—Chris

The differences between Buzz Packs and alcohol

Alcohol wreaks havoc on your liver from the moment you take a sip. Your liver must detoxify ethanol by converting it to acetaldehyde, a highly toxic compound that damages liver cells directly. This process triggers inflammation, oxidative stress, and cellular death that can cause permanent liver damage.

Here's how Buzz Packs compare to alcohol when it comes to liver health:

• Alcohol produces acetaldehyde that destroys liver cells. Buzz Packs don't create any toxic compounds during metabolism.
• Alcohol directly causes alcoholic hepatitis, fibrosis, and cirrhosis. Cannabinoids at low doses show no similar disease-causing effects.
• Alcohol is linked to liver cancer. THC and CBD help fight liver cancer cells.
• Alcoholic drinks pack hundreds of calories that contribute to fatty liver. Each Buzz Pack contains just 3 calories.
• Alcohol disrupts deep sleep, which impairs liver recovery. Buzz Packs support healthier sleep patterns essential for liver health.
• Alcohol raises cortisol levels that damage liver tissue. Buzz Packs help lower stress hormones that harm the liver.
• Alcohol causes hangovers that further strain an already taxed liver. Buzz Packs provide effects without the next-day liver burden.

People who switch from alcohol to our Buzz Packs or Buzz Drops™ often show improved liver enzyme profiles in just a few weeks. These low-dose products are a smarter choice for liver health while still providing a mild buzz.

Where to buy Buzz Packs

nama exclusively produces and sells Buzz Packs because we want you to get the highest quality product every time. Our rigorous lab tests show our commitment to purity, with results you can check yourself anytime. We extract THC and CBD from 100% organic, non-GMO, American-grown hemp to create these convenient cannabis powder packets.

Sign up for our personalized Buzz Packs subscription and we'll deliver them right to your door automatically. You'll save time and never worry about running low or having to reorder.

Resources

Chen S, Kim JK. The Role of Cannabidiol in Liver Disease: A Systemic Review. Int J Mol Sci. 2024 Feb 17;25(4):2370. doi: 10.3390/ijms25042370. PMID: 38397045; PMCID: PMC10888697.

Zhu J, Peltekian KM. Cannabis and the liver: Things you wanted to know but were afraid to ask. Can Liver J. 2019 Aug 27;2(3):51-57. doi: 10.3138/canlivj.2018-0023. PMID: 35990221; PMCID: PMC9202751.

Gorelick, J., Assa-Glazer, T., Zandani, G. et al. THC and CBD affect metabolic syndrome parameters including microbiome in mice fed high fat-cholesterol diet. J Cannabis Res 4, 27 (2022). https://doi.org/10.1186/s42238-022-00137-w

Zhang, S., Ma, C., Wang, X., Wang, Q., Song, W., Li, C., Zhai, C., Qi, Y., Fan, S., & Cheng, F. (2019). Impact of chronic psychological stress on nonalcoholic fatty liver disease.

Yang L, Rozenfeld R, Wu D, Devi LA, Zhang Z, Cederbaum A. Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy. Free Radic Biol Med. 2014 Mar;68:260-7. doi: 10.1016/j.freeradbiomed.2013.12.026. Epub 2014 Jan 4. PMID: 24398069; PMCID: PMC4112960.

Further reading

Are Buzz Drops harming your liver?

The proper way to use Buzz Packs

Do Buzz Packs really work?

The duration of Buzz Packs’ effects

What are the effects of Buzz Packs on hunger?

Why do THC drinks hit faster than gummies?

The psychoactive potential of THC mocktails

What are Buzz Packs good for?

nama CBD FDA & legal disclaimer

Our products are not intended to diagnose, treat, cure, or prevent any disease. They are not a replacement for prescription medications and have not been evaluated by the U.S. Food and Drug Administration (FDA).

The information provided on this website does not and is not intended to, constitute legal advice or any statement of the status of any laws. Any information, content, and materials available on this site are for general informational purposes only and are not intended to be relied upon for any purpose.

Readers of this website should contact their attorney to obtain advice with respect to any particular legal matter, including decisions on what products are, or are not, legal to sell, possess, or consume. No reader, user, or browser of this site should act or refrain from acting on the basis of the information on this site without first seeking legal advice from their own counsel in the relevant jurisdiction.+