Is CBD good for nausea?

Mar 26, 2025The nama Team
Is CBD good for nausea? by namaCBD

Cannabidiol (CBD) is a natural alternative to anti-nausea medications because it calms your queasy stomach without leaving you feeling drowsy and disconnected. CBD works with your body's built-in regulatory system to restore balance. 

Our low-dose full-spectrum CBD gummies deliver enough cannabidiol to ease your nausea while allowing you to stay present and functional throughout your day. Our edibles introduce you to the benefits of microdosing, where small amounts of CBD and THC provide gentle relief that doesn't overwhelm your system.

How does CBD reduce nausea?

CBD delivers powerful relief for upset stomachs by activating your endocannabinoid system (ECS), the body's built-in regulator of digestive function and gut health. Specialized ECS receptors throughout your digestive tract respond to CBD by calming the inflammatory responses that trigger nausea.

The primary mechanism involves CBD's activation of serotonin receptors (specifically 5-HT1A) in the dorsal raphe nucleus. According to Parker, et. al., this activation reduces the release of serotonin in regions that trigger nausea signals, suppressing nausea at its neurological source before you even feel it. CBD disrupts nausea before it intensifies without the sedative effects of conventional medications.

In the digestive tract, this non-psychoactive component of cannabis interacts with the complex cannabinoid receptor network. Cannabis extracts containing CBD help maintain the integrity of your stomach lining, creating a protective barrier against toxin-induced nausea that conventional medications often can't address. This protection extends to the cellular level, where CBD modulates mast cell activity to reduce histamine production that can trigger queasiness.

A 2016 study reveals that CBD soothes stomach issues by:

  • Reducing digestive tract inflammation by blocking inflammatory compounds.
  • Normalizing stomach acid production to prevent excess acidity.
  • Protecting stomach lining by strengthening the natural barrier against irritants.
  • Interrupting pain and nausea signals in the gut-brain communication pathway.
  • Breaking the anxiety-stomach pain cycle by reducing stress hormones.

Researchers from Stanford University reveal that CBD helps chemotherapy patients by activating CB1 receptors in the brain's dorsal vagal complex and inhibiting the release of excitatory neurotransmitters that trigger the emetic reflex. Combinations with near-equal ratios of CBD and THC are better at reducing nausea than placebo in patients undergoing highly emetogenic chemotherapy, with most patients reporting improved quality of life.

Microdosing with small amounts of CBD and THC provides superior nausea relief without the drowsiness, constipation, or mental fog associated with traditional treatments. This combination manages different forms of nausea including chemotherapy-induced nausea, motion sickness, anticipatory nausea before treatments, and stress-related digestive discomfort.

Ready to feel better without feeling "out of it"? Our Relax Plus gummies deliver 25 mg of CBD and 5 mg of THC, giving you powerful nausea relief that keeps you present and functional throughout your day.

“These gummies taste great and are wonderful after a hard day at work. They help you unwind and leave your stress behind…”

Tammy M.

What is the best CBD ratio for nausea?

The right CBD dosage for nausea relief depends on when you need it most. While CBD alone can relieve nausea, adding even small amounts of THC enhances its effects through what's known as the entourage effect. In the entourage effect, cannabis compounds work together to provide stronger relief than either could alone.

For daytime relief when you need to stay functional, formulations with more CBD than THC (5 parts CBD to 1 part THC, or 10:1) calm nausea without clouding your thinking or affecting your ability to drive. These ratios provide the entourage effect's benefits while minimizing THC's potential psychoactive effects.

Those who battle severe nausea (like chemotherapy-induced nausea) respond best to equal parts CBD and THC (1:1 ratio), as found in our Bliss gummies. Five mg of each delivers powerful relief. If you’re experiencing nausea before bed or discomfort from sleep issues, try formulations with more THC than CBD (1 part CBD to 2 parts THC). Their added sedative benefits help you drift to sleep while the nausea subsides, turning what could be a night of discomfort into peaceful rest.

Whichever balance you choose, start with low doses and adjust to find what works best for your body.

How long does CBD stay in your system?

CBD circulates in your system for 2–5 days. The duration depends on your body chemistry and metabolism, but the frequency and method of use also determine elimination speed. 

  • Edibles release CBD slowly, keeping anti-nausea effects active for 4–6 hours. Trace amounts remain detectable for up to 5 days. 
  • CBD drinks work faster but exit your system quicker, typically clearing within 2–3 days. 
  • Smoked or vaped CBD delivers immediate relief but stays in your system the shortest time, usually clearing within 1–2 days.

Microdosing with therapeutic combinations of THC and CBD eliminates nausea without triggering drug interactions or tolerance buildup. Our low-dose THC gummies deliver this ideal balance, controlling your symptoms of nausea without side effects. 

If drug tests concern you or you don’t want THC’s mild effects circulating your system, try our broad spectrum CBD edibles. These gummies contain no THC but still deliver powerful anti-nausea relief through CBD's action on your digestive system and brain chemistry.

Are there side effects when taking CBD for nausea?

CBD delivers nausea relief with minimal drawbacks. Side effects are rare even at higher doses, though microdosing balances symptom control without unwanted reactions. 

Those new to cannabis or trying higher doses may experience a few minor side effects, but these typically fade quickly. These potential side effects include:

  • Temporary dry mouth.
  • Mild drowsiness.
  • Changes in appetite.
  • Slightly lowered blood pressure.
  • Potential medication interactions through liver enzyme pathways.

Always check product certificates of analysis for quality and purity. With namaCBD, you don’t have to worry about what goes into our products. We provide third-party lab results for every batch we produce. Our quality commitment means you're getting what's on the label—nothing more, nothing less.

Order now, and taste the quality in every bite.

Product QUIZ

Need help deciding what product is best for you? Take our quiz, just three questions until your perfect match!

When shouldn’t you use CBD for nausea?

Despite CBD's impressive safety profile, certain situations require caution. You should avoid or use CBD with medical supervision if you:

  • Take medications with a "grapefruit warning" (including certain blood thinners and anti-seizure drugs).
  • Are pregnant or breastfeeding.
  • Have pre-existing liver conditions.
  • Experience cannabis hyperemesis syndrome.
  • Have a history of adverse reactions to medicinal cannabis.

For pregnancy-related nausea, consult your healthcare provider about alternatives, like vitamin B6 or ginger. Cancer patients and those undergoing chemotherapy treatment should discuss potential drug interactions with their oncology team before starting CBD, particularly during cycles of treatment.

What are the best CBD gummies for nausea?

Our low-dose gummies and cannabis beverages target different types of nausea while fitting into your daily routine, no matter when symptoms strike.

Energy gummies (5 mg CBD, 2.5 mg THC)

Energy gummies deliver daytime relief when functionality matters most. The minimal THC content provides just enough entourage effect without cognitive impairment. This delicious gummy is useful for cancer patients who need to maintain daily activities despite treatment-related nausea.

Relax Plus gummies (25 mg CBD, 5 mg THC)

Relax Plus gummies are best for intense chemotherapy-induced nausea with a higher CBD concentration that maximizes therapeutic benefits through multiple neural pathways. The 5:1 CBD ratio creates powerful relief while minimizing psychoactive effects, which makes them effective for patients facing treatment cycles when standard antiemetic regimens prove insufficient.

Melatonin sleep edibles (25 mg CBD, 5 mg CBN, 3 mg melatonin)

Our melatonin sleep gummies address nighttime nausea that disrupts rest and recovery. The CBD calms gastric distress through cannabinoid receptors, while CBN provides additional sedative properties. This specialized formulation helps prevent the cycle of sleep disruption that often accompanies cancer treatments, without risking cannabis hyperemesis syndrome that can occur with higher-dose products.

Buzz Packs™ (5 mg CBD, 5 mg THC)

Our THC powder drink mix offers fast-acting relief for sudden nausea. A balanced cannabinoid profile works through central and peripheral pathways to quickly calm digestive distress. A liquid delivery system provides gentler absorption for sensitive stomachs, making powder mix an easy remedy for patients experiencing anticipatory nausea before treatments.

Learn how to craft delicious THC mocktails with our Buzz Packs and equally easy-to-use Buzz Drops™, and up your cannabis game. Both contain microdoses of CBD and THC, so you know you’ll get plenty of sweet, mild euphoria without adverse effects.

All our cannabis edibles are federally compliant. Broad-spectrum (zero THC) options are available in all 50 states, while our hemp-derived Delta 9 THC products are legal everywhere except Idaho and Kansas.

Shop nama today and experience nausea relief, naturally. With free shipping wherever you are, there's no reason to suffer through another day of queasiness and discomfort.

CBD for nausea FAQ

CBD is a non-psychoactive compound in cannabis which means it doesn’t make you feel high (the same way THC does). It interacts with the endocannabinoid system to influence mood, relaxation, and discomfort. Unlike THC, it does not induce a "high" but regulates serotonin receptors to reduce stress and promote calm. CBD alleviates mild discomfort, improves sleep, and eases nausea. The effects of CBD are very subjective; some feel energized, while others experience drowsiness.

CBD and cannabigerol (CBG) target nausea differently. CBD influences serotonin receptors in the dorsal raphe nucleus, potentially reducing anticipatory nausea. CBG engages the endocannabinoid system to regulate gastrointestinal function. CBD sees more frequent use for nausea relief, but CBG’s role in gut health may offer additional benefits. More research is warranted to determine which compound proves more effective in controlling nausea and vomiting.

Pure CBD should not trigger a failed drug test, but full-spectrum CBD often contains trace THC. Even small THC concentrations can surpass test detection limits. Certificates of analysis from reputable manufacturers confirm THC-free status, yet some synthetic cannabinoids cause false positives. Certain screening tests misidentify non-psychoactive cannabinoids. To avoid risk, consumers should choose CBD isolate or broad-spectrum products with verified lab results.

CBD helps you feel good by promoting relaxation and balance in your body. It interacts with brain receptors that regulate mood, stress, and discomfort, which is why many people find it eases anxiety, improves sleep, and relieves mild aches. It may also help with nausea and inflammation. Unlike THC, CBD doesn’t cause a high—it creates a sense of calm and well-being without affecting your clarity or focus.

While CBD is known for reducing nausea, it’s not recommended for morning sickness due to safety concerns during pregnancy. CBD affects serotonin receptors, which play a role in nausea control, but there isn’t enough clinical data to confirm its safety for pregnant women. 

Many healthcare professionals acknowledge CBD’s anti-nausea effects, yet cannabis use during pregnancy has been linked to potential risks, including developmental issues in the baby. Since CBD products can contain trace amounts of THC and lack strict regulation, they may pose unknown risks. Doctors typically recommend safer alternatives such as ginger or vitamin B6. Always consult a healthcare provider before using CBD during pregnancy.

CBD's anti-inflammatory properties may help with gastritis by calming stomach irritation and regulating gut function. It interacts with serotonin and CB2 receptors, which influence gastrointestinal inflammation. CBD alleviates gastric discomfort and nausea, though clinical trials remain scarce. Some report relief from pain and bloating, yet scientists have not determined CBD’s effect on gastric acid production or long-term safety

CBD may help with bloating and gas by influencing gut motility and reducing inflammation. It interacts with serotonin and CB2 receptors, which play key roles in digestion. Many people with irritable bowel syndrome (IBS) or gastrointestinal discomfort report symptom relief with CBD. Some evidence points to its ability to relax the muscles of the digestive tract, which may ease bloating. However, there isn’t enough data to confirm its effectiveness, and more research is needed to understand its role in gas relief.

The effect of CBD on gastric emptying is unclear. Cannabinoids can influence digestion, and some findings indicate a slowdown in gut motility, while others show little to no impact. THC appears to have a stronger effect in delaying digestion, whereas CBD’s role remains unclear. If you’re concerned about digestive function, speak with a healthcare provider before using CBD, as its influence on gastric emptying has yet to be fully understood.

CBD is generally safe for the liver and well tolerated, but high doses may affect liver enzymes and interfere with drug metabolism. Clinical reports show that CBD drastically reduced elevated levels of two major liver enzymes in mice with induced liver failure without affecting enzyme levels in healthy control animals, showing a normalizing rather than suppressive effect on liver function. While CBD itself is unlikely to cause harm in moderate doses, contaminated or synthetic products pose additional risks.

Top Sellers

New? Start with our Ultimate Sampler!
Buzz Packs™ [THC and CBD Powder Drink Mix]
Buzz Packs™ [THC and CBD Powder Drink Mix]
On Sale from $29.95
Buzz Packs™ [THC and CBD Powder Drink Mix]

THC: 5 mg | CBD: 5 mg (per serving)

Save up to $50.00 THC
Pain Plus Gummies
Pain Plus Gummies
From $49.00
Pain Plus Gummies

THC: 10 mg | CBC: 10 mg | CBD: 10 mg | CBG: 5 mg | CBN 5mg

THC
The Ultimate nama Sampler
The Ultimate nama Sampler
On Sale from $19.95
The Ultimate nama Sampler
Save $4.05 THC
Buzz Drops™ [THC Drink Drops]
Buzz Drops™ [THC Drink Drops]
On Sale from $27.95
Buzz Drops™ [THC Drink Drops]

THC: 2.5 mg | CBD: 2.5 mg (per serving)

Save up to $42.00 THC
Energy Gummies
Energy Gummies
From $27.00
Energy Gummies

THC: 2.5 mg | CBD: 5 mg

THC

Resources

Parker LA, Rock EM, Limebeer CL. Regulation of nausea and vomiting by cannabinoids. Br J Pharmacol. 2011 Aug;163(7):1411-22. doi: 10.1111/j.1476-5381.2010.01176.x. PMID: 21175589; PMCID: PMC3165951.

Gyires K, Zádori ZS. Role of Cannabinoids in Gastrointestinal Mucosal Defense and Inflammation. Curr Neuropharmacol. 2016;14(8):935-951. doi: 10.2174/1570159x14666160303110150. PMID: 26935536; PMCID: PMC5333598.

Bathula PP, Maciver MB. Cannabinoids in Treating Chemotherapy-Induced Nausea and Vomiting, Cancer-Associated Pain, and Tumor Growth. Int J Mol Sci. 2023 Dec 20;25(1):74. doi: 10.3390/ijms25010074. PMID: 38203245; PMCID: PMC10779013.

Avraham Y, Grigoriadis N, Poutahidis T, Vorobiev L, Magen I, Ilan Y, Mechoulam R, Berry E. Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice. Br J Pharmacol. 2011 Apr;162(7):1650-8. doi: 10.1111/j.1476-5381.2010.01179.x. PMID: 21182490; PMCID: PMC3057300.

Further reading

Can CBD help me with insomnia?

Microdosing CBD for flying anxiety

Are Buzz Packs safe to consume?

Why is CBD good for focus and concentration?

Is it safe to take CBD for ADHD symptoms?

Why is hybrid weed better for nausea relief?

Best CBD gummies for nausea relief

nama CBD FDA & legal disclaimer

Our products are not intended to diagnose, treat, cure, or prevent any disease. They are not a replacement for prescription medications and have not been evaluated by the U.S. Food and Drug Administration (FDA).

The information provided on this website does not and is not intended to, constitute legal advice or any statement of the status of any laws. Any information, content, and materials available on this site are for general informational purposes only and are not intended to be relied upon for any purpose.

Readers of this website should contact their attorney to obtain advice with respect to any particular legal matter, including decisions on what products are, or are not, legal to sell, possess, or consume. No reader, user, or browser of this site should act or refrain from acting on the basis of the information on this site without first seeking legal advice from their own counsel in the relevant jurisdiction.

More articles

Comments (0)

There are no comments for this article. Be the first one to leave a message!

Leave a comment

Please note: comments must be approved before they are published