Can hybrid weed alleviate nausea?

Try hybrid weed for nausea. It merges indica's body comfort with sativa's clear head to hit the sweet spot between too sleepy and too wired. You can pick hybrid strains that reduce symptoms related to morning sickness, chemo nausea, or motion sickness without throwing off your day.

The best way to reap hybrid benefits is through our perfectly microdosed edibles. Pop one and enjoy gentle, balanced relief without guesswork.

What type of nausea is hybrid weed good for?

Hybrid cannabis strains are carefully bred combinations of indica and sativa plants that offer a balanced approach to nausea relief by harnessing the unique therapeutic properties of both varieties. Their balanced effects relieve a variety of nausea types such as:

• Chemotherapy-induced nausea: delivers soothing effects for chemotherapy patients and eases the queasiness that often accompanies treatment.
• Stress-related nausea: brings calming effects to reduce nausea linked to stress or anxiety.
• Digestive discomfort: serves as a natural remedy for nausea associated with irritable bowel syndrome (IBS) and other digestive issues.
• Motion sickness: offers balanced support for those struggling with nausea from travel.
• Hangover nausea: acts as a natural alternative for alleviating post-alcohol queasiness.

How do hybrid strains target nausea?

While pure indicas can be too sedating and pure sativas might increase anxiety, hybrids strike an optimal balance of effects that's particularly effective for managing nausea.

Here are the benefits of hybrids for nausea relief:

• Hybrid strains combine THC and CBD with diverse terpenes to create a more potent entourage effect and deliver superior nausea relief.
• Hybrids offer precise control over your relief by letting you choose between indica-dominant strains for evening use or sativa-dominant varieties for daytime relief without compromising functionality.
• Hybrid strains target the symptoms of nausea and underlying causes by combining sativa's energizing, mood-lifting properties with indica's calming, stomach-settling effects.
• The balanced effects of hybrids provide mental clarity and physical comfort.
• The diverse cannabinoid profile in hybrids manages multiple nausea symptoms simultaneously. It relieves nausea while improving appetite, reducing anxiety, and easing physical discomfort.
• Hybrid strains can be tailored to individual needs through different THC-CBD ratios. This allows for personalized relief while minimizing the potential side effects of hybrids.

Through their unique combination of diverse cannabinoids and terpenes, hybrids unlock the full therapeutic potential of microdosing cannabis in a way that single compounds or pure strains simply cannot match.

Get the perfect daytime boost with Energy gummies. Each one packs a microdose of 2.5 mg of tetrahydrocannabinol (THC) and 5 mg of CBD to gently lift your spirits. They allow you to stay focused and energized while easing any discomfort or nausea.

“I love these. My favorite by far. Just one and I'm able to shut my brain up long enough to get things done. And the flavor is wonderful…”

—Meghan

How does cannabis work to relieve nausea?

Cannabis excels at fighting nausea. Cannabinoids such as THC and CBD target the brain and gut through the body's endocannabinoid system (ECS). This natural network of receptors controls vital functions such as nausea, appetite, and digestion, which is why cannabis can quickly stop nausea signals from both ends.

Cannabis fights nausea through multiple mechanisms.

1. THC binds to brainstem receptors to block nausea at its source.
2. THC controls dopamine signals that trigger the vomiting reflex.
3. Cannabis regulates gut-brain communication to stop nausea signals.
4. Cannabis blocks serotonin release that tells the brain to feel nauseous.
5. CBD and THC reduce stomach acid that triggers nausea.
6. Cannabinoids lower inflammation which causes an upset stomach.
7. THC protects the stomach lining from nausea-triggering irritation.
8. THC and CBD work together to provide complete nausea relief.

One: THC binds to brainstem receptors to block nausea at its source

THC targets the brain's nausea command center in the endocannabinoid system where CB1 receptors concentrate. By activating these receptors, THC provides quick relief from nausea symptoms while minimizing psychoactive effects when you consume it in lower, controlled amounts (microdosing). 

Sharkey, et. al. show that THC modulates neurotransmitters and calcium channels, making the brain less reactive to diverse nausea triggers. THC also targets CB1 receptors in the brain's dorsal vagal complex and vomiting center to nausea signals before they start while suppressing the vomiting reflex. 

Two: THC controls dopamine signals that trigger the vomiting reflex

THC interacts with dopamine receptors to reduce nausea and mitigate the vomiting reflex. It activates CB1 receptors specifically in the brain's chemoreceptor trigger zone, where dopamine signals normally trigger nausea and vomiting. Excess dopamine in this area causes nausea, but THC blocks these dopamine-releasing neurons from firing and prevents the nausea response. 

Interestingly, THC only blocks dopamine signals in the nausea pathway while preserving dopamine activity in other brain regions that control mood and well-being. This selective action explains why cannabis can stop nausea without causing sedation or blocking dopamine's positive effects on mood.

Three: Cannabis regulates gut-brain communication to interfere with nausea signals

Cannabis acts as a master regulator of gut-brain communication. The gut and brain are in constant communication through the vagus nerve, so when something irritates your stomach, these areas immediately signal the brain's nausea center to trigger the feeling of sickness and potential vomiting.

THC and cannabidiol (CBD) target CB1 receptors located along the entire gut-brain pathway, including in the brain's dorsal vagal complex and intestinal cells. A 2011 study demonstrated that this dual action allows cannabis to block peripheral and central nausea triggers by suppressing serotonin release in the gut and inhibiting nausea circuits in the brain.

Cannabis regulates dopamine, serotonin, and other “feel-good” neurotransmitters to regulate emotions, happiness, and overall psychological health. Experience the perfect balance of calm and clarity with Bliss gummies. Five mg of THC and CBD each let you feel good without feeling overwhelmed.

Read more about the beneficial effects of low-dose cannabis on mental health.

Four: CBD and THC reduce stomach acid that triggers nausea

CBD's interaction with specialized stomach cells relieves medical conditions that involve acid-related nausea. For example, CBD interacts with mast cells that produce histamine to reduce the number of histamine receptors in the gut.

Histamine is a neurotransmitter and inflammatory mediator that triggers the vomiting reflex when stimulated by certain drugs and toxins. This antihistamine mechanism also shows promise for stress-related gastrointestinal disorders, where CBD's dual action provides immediate relief and long-term regulation. 

Five: Cannabinoids lower inflammation that causes stomach upset

The anti-inflammatory properties of cannabis reduce nausea by blocking inflammatory compounds (cytokines and interleukins) that trigger nausea signals. THC and CBD work together to decrease gut inflammation, with CBD specifically inhibiting inflammatory cytokines while THC helps maintain the protective barrier of the stomach lining. 

Cannabis and/or cannabinoids protect the gastric mucosa against noxious challenge with non-steroidal anti-inflammatory drugs, ethanol as well as against stress-induced mucosal damage. Cannabis/cannabinoids might protect the gastric mucosa by virtue of its antisecretory, antioxidant, anti-inflammatory, and vasodilator properties. (Abdel-Salam)

This dual anti-inflammatory action restores normal communication between the gut and brain to soothe the feelings of nausea.

Six: THC protects the stomach lining from nausea-triggering irritation

Cannabis strengthens the stomach's natural protective barrier which directly ameliorates feelings of nausea. This happens through reducing excess acid, providing antioxidant effects, improving blood flow, and fighting inflammation in the stomach lining. Leinen, et. al. posit that this protective effect shields the stomach against damage from medications, alcohol, and stress that could otherwise trigger nausea. 

Seven: Cannabis breaks the anxiety-nausea cycle through stress relief

When you're anxious, your brain releases stress hormones that throw your gut into chaos. These hormones increase stomach acid, disrupt digestion, and trigger nausea that only makes your anxiety worse. Cannabis breaks the cycle between anxiety and nausea. CBD lowers the levels of stress hormones while normalizing acid production in the stomach. 

Both CBD and THC interact with serotonin receptors to boost mood and reduce anxiety symptoms. Canadian researchers explain that CBD activates serotonin receptors (5-HT1A) in the brain called the dorsal raphe nucleus, which helps regulate mood and anxiety. By activating these receptors, CBD indirectly reduces nausea signals. Blocking these serotonin receptors prevented CBD's anti-nausea effects in rats and shrews.

Find your calm and settle your stomach with Relax Plus gummies. These tasty treats feature a gentle 5 mg THC and balanced 25 mg CBD blend for natural anxiety and nausea relief. 

Eight: THC and CBD work together for complete nausea control

THC and CBD work more effectively together than alone, creating a powerful synergy known as the entourage effect. While THC directly blocks nausea signals in the brain, CBD enhances its effects while reducing the potential psychoactive impacts of THC. 

This dynamic duo doesn't work in isolation. The entourage effect is supported by hundreds of other natural compounds found in cannabis, including terpenes and flavonoids, that amplify their therapeutic benefits. Hybrid cannabis strains offer the perfect blend of these compounds to optimize the entourage effect for maximum relief from nausea. 

Experience the perfect cannabis microdose with our hybrid THC gummies. We created a wide spectrum of delicious edibles to combine the mood-lifting benefits of sativa with indica's calming comfort for balanced, gentle relief. 

What are the best terpenes for nausea?

Terpenes are aromatic compounds naturally found in cannabis and many other plants. These fragrant molecules give cannabis its distinctive smell and taste, but they also work alongside cannabinoids to enhance therapeutic effects. Many of them have powerful anti-nausea, anti-inflammatory, and calming properties that enhance the effects of THC and CBD.

Because of their richer cannabinoid profile, hybrid strains produce a more diverse and concentrated blend of beneficial terpenes than pure indica or sativa strains. Here are the five best terpenes for nausea relief found in hybrid cannabis:

1. Limonene is a terpene with energizing and uplifting effects. It settles digestive issues and provides quick relief from queasiness while elevating mood.
2. Pinene reduces inflammation throughout the digestive system while maintaining mental clarity. Its anti-inflammatory properties make it especially valuable for chronic nausea conditions.
3. Caryophyllene is the only terpene known to directly activate cannabinoid receptors. This peppery compound provides powerful relief from digestive discomfort and gut inflammation. 
4. Myrcene is a relaxing terpene that eases nausea-triggering physical tension while promoting healthy digestion.
5. Linalool reduces the anxiety that can trigger nausea while gently settling the stomach. It's particularly effective for stress-related digestive issues and anticipatory nausea.

These hybrid terpenes defeat inflammation and anxiety—the two biggest triggers of nausea—which is why they're so effective at providing natural, complete relief. When combined with THC, CBD, and other cannabis elements in the entourage effects, the result is stronger and more complete nausea relief than any single compound could achieve alone.

Our entourage effect gummies harness the full entourage effect of hybrid weed strains through a rich blend of terpenes and cannabinoids. We combine THC and CBD in precisely balanced ratios that maximize their anti-nausea benefits while minimizing side effects for natural comfort that pure strains simply can't match.

Best hybrid strains for nausea

Through years of cultivation and patient feedback, certain hybrids have become more effective at providing quick and lasting relief. These strains combine optimal ratios of cannabinoids and terpenes beneficial for settling the stomach and easing discomfort. 

Here are the top six hybrid strains for nausea relief:

1. Blue Dream
2. Girl Scout Cookies
3. OG Kush
4. Wedding Cake
5. Zkittlez
6. Gelato

With nama™, you get the perfect blend of hybrid strains for nausea relief throughout your day. Our balanced products combine the best anti-nausea properties of multiple strains in microdoses of just 2–10 mg of THC to feel the benefits while staying clear-headed and comfortable.

What are the best hybrid edibles for nausea relief?

nama offers the perfect lineup of low-dose cannabis gummies and beverages for natural nausea relief. Here are our best hybrid edibles for fighting nausea:

1. Bliss gummies (5 mg THC, 5 mg CBD) provide fast nausea relief through an equal ratio of THC and CBD that settles your stomach while lifting your mood. The balanced cannabinoid profile helps fight nausea without feeling overly sedated or stimulated.
2. Energy gummies (2.5 mg THC, 5 mg CBD) combine a gentle amount of THC with extra CBD to reduce nausea while keeping you focused and energized. Perfect for daytime use when you need nausea relief without drowsiness, plus the added B12 and L-theanine enhance mental clarity.
3. Relax Plus gummies (5 mg THC, 25 mg CBD) are ideal for soothing nausea and anxiety, especially when stress is triggering your stomach issues. The extra CBD helps maximize the anti-nausea benefits while minimizing THC side effects.
4. Buzz Drops (2.5 mg THC, 2.5 mg CBD per dropper) aren’t exactly gummies, but these 
5. versatile liquid drops let you transform any drink into a therapeutic nausea-fighting beverage. Their perfectly balanced micro-dose of THC and CBD is effortlessly mixed into sparkling water, juice, or your favorite mocktail for fast-acting relief that soothes your stomach while keeping you clear-headed. The liquid format allows for quick absorption and precise dosing control.

We've refined hybrid cannabis edibles to deliver targeted nausea relief with precision. Our products are made from premium, non-GMO American hemp for a clean, effective experience. Partnering with small organic farms in Colorado and New Jersey, each product is 100% American-made and thoroughly tested for quality.

What makes our hybrid gummies and cannabis-infused drinks unique is their expertly balanced formula. They are designed to ease discomfort—be that aches, stress, nausea, or sleep disturbances—without disrupting your day. They also fit into any routine, whether you're unwinding after work or need quick relief on the go. Just pop a gummy or add a few drops to your drink, and you're set for calm and comfort whenever you need it.

Best of all, our Delta 9 products are federally compliant and available for online orders with delivery to 48 U.S. states (read our state-to-state Delta 9 legality guide for more information). 

Discover the nama approach where innovative cannabis science meets everyday wellness.

Resources

Sharkey, K. A., Darmani, N. A., & Parker, L. A. (2013). Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system. European Journal of Pharmacology, 722, 10.1016/j.ejphar.2013.09.068. https://doi.org/10.1016/j.ejphar.2013.09.068

Parker, L. A., Rock, E. M., & Limebeer, C. L. (2011). Regulation of nausea and vomiting by cannabinoids. British Journal of Pharmacology, 163(7), 1411. https://doi.org/10.1111/j.1476-5381.2010.01176.x

Abdel-Salam, O. (2016). Gastric acid inhibitory and gastric protective effects of Cannabis and cannabinoids. Asian Pacific Journal of Tropical Medicine, 9(5), 413-419. https://doi.org/10.1016/j.apjtm.2016.04.021

Leinen, Z. J., Mohan, R., Premadasa, L. S., Acharya, A., Mohan, M., & Byrareddy, S. N. (2023). Therapeutic Potential of Cannabis: A Comprehensive Review of Current and Future Applications. Biomedicines, 11(10), 2630. https://doi.org/10.3390/biomedicines11102630

Rock EM, Bolognini D, Limebeer CL, Cascio MG, Anavi-Goffer S, Fletcher PJ, Mechoulam R, Pertwee RG, Parker LA. Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus. Br J Pharmacol. 2012 Apr;165(8):2620-34. doi: 10.1111/j.1476-5381.2011.01621.x. PMID: 21827451; PMCID: PMC3423241.

Further reading

What does hybrid weed feel like?

Is hybrid better than sativa?

Is hybrid weed stronger than sativa?

The relaxing effects of hybrids

Sativa, indica, or hybrid weed for pain relief

The anti-inflammatory action of hybrid weed

What is the best cannabis strain for socializing?

Why is hybrid weed great at relieving chronic fatigue?

What is the best weed for multiple sclerosis patients?

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