What terpenes are good for nausea relief?

Nausea relief starts with cannabis terpenes, aromatic plant compounds that target discomfort at its source. With the help of other cannabis compounds, terpenes dive deep into your body's systems to block nausea signals in your brain and soothe your upset stomach. 

We’ll look at the six most potent cannabis terpenes for nausea relief and introduce you to the best way to use them.

Discover the best microdosed THC gummies infused with nausea-relieving terpenes, soothing cannabinoids, and other natural compounds for calming relief.

What do cannabis terpenes do?

Terpenes are organic compounds that give cannabis its unique array of scents and flavors. These natural compounds play a vital role in how cannabis relieves nausea and digestive discomfort. 

The reason you can detect different cannabis aromas is because of terpenes' volatile nature. They readily evaporate at room temperature, releasing their distinctive scents into the air. This property makes them highly bioavailable, so our bodies can easily absorb them through consumption.

Here’s what cannabis terpenes do:

• They provide powerful anti-inflammatory properties that reduce swelling and irritation in joints, muscles, and internal systems.
• They support healthy biological rhythms and natural cycles by interacting with receptors that regulate sleep, digestion, and hormone production.
• They act as natural muscle relaxants: they ease tension, reduce spasms, and promote physical relaxation without sedation.
• They interact with the nervous system to regulate pain signals, stress responses, and mood.
• They work synergistically with the endocannabinoid system (ECS) to enhance the body's natural ability to maintain balance and respond to stress.
• They regulate appetite and metabolism by influencing the brain's digestive enzymes and hunger signals.
• They support cognitive function by promoting healthy blood flow to the brain and protecting neural tissue through antioxidant effects.
• They promote restful sleep by regulating circadian rhythms and calming an overactive mind.

Terpenes exist throughout the plant kingdom, but cannabis strains, especially hybrid weed, contain particularly diverse terpene profiles that work together to ease stomach pain. 

Are terpenes good for digestive health?

According to a 2020 review on the intestinal anti-inflammatory properties of terpenes, these compounds work directly with your body's digestive system to:

• Reduce inflammation.
• Ease muscle tension.
• Settle an upset stomach.
• Regulate acid production.
• Reduce cramping.
• Support a healthy appetite.
• Calm the nerves that trigger nausea and stomach discomfort.
• Maintain healthy gut function.
• Regulate the entire digestive process.

Terpenes work alongside other cannabis compounds, producing the “entourage effect” and enhancing their natural ability to provide digestive relief and comfort. When different terpenes and cannabis compounds combine, they become more effective than when used alone. For digestive health, this creates a more complete form of relief. While one terpene might target inflammation, another could ease muscle tension, and a third might regulate stomach acid—all working in harmony to support your digestive wellness.

Through their diverse array of terpenes and cannabinoids, cannabis hybrids deliver remarkable therapeutic benefits that single compounds or pure strains cannot replicate. Microdosing cannabis, with its precise and gentle approach, harnesses the power of terpenes to soothe nausea and stomach discomfort. 

Experience the balancing effects of our Energy gummies that offer a microdose of 2.5 mg of THC and 5 mg of CBD to ease digestive unease while keeping you calm, focused, and ready to take on your day.

“I love these. My favorite by far. Just one and I'm able to shut my brain up long enough to get things done. And the flavor is wonderful…”

—Meghan

How do terpenes relieve nausea?

Terpenes fight nausea through precise biological actions in your digestive system. Here’s what the research says about the antiemetic properties of cannabis terpenes:

• Canadian researchers discovered that terpenes bind to CB1 receptors in the brain's dorsal vagal complex to block nausea signals. At the same time, they activate serotonin receptors that regulate stomach discomfort and queasiness. 
• A 2023 review found that some terpenes inhibit the production of pro-inflammatory compounds in the gut by suppressing cyclooxygenase-2 (COX-2) and inflammatory cytokines that can trigger nausea. Other terpenes work through the vanilloid TRPV1 receptors in the nervous system to regulate nausea signals and maintain normal digestive function.
• A 2021 Australian study sheds light on the role of anandamide in soothing nausea. Anandamide is our body's natural cannabis-like molecule that activates CB1 receptors in the brain to suppress nausea signals and regulate digestion. Through the ECS, some terpenes enhance endogenous anandamide levels which regulate digestive function. 

Cannabis contains hundreds of different terpenes, but only certain ones have been scientifically shown to effectively combat nausea through these biological mechanisms. 

Best terpenes for nausea relief

Here are six research-backed terpenes that excel at relieving nausea:

1. Limonene: This citrusy terpene directly reduces acid reflux by regulating stomach acid production. It calms digestive spasms that can trigger nausea. Limonene also works through the brain's serotonin pathways to reduce nausea signals.
2. Beta-caryophyllene: This powerful anti-inflammatory terpene activates CB2 receptors to reduce gut inflammation that can cause nausea. It maintains healthy gut barrier function and reduces inflammatory cytokines. It works synergistically with other cannabinoids to enhance nausea relief.
3. Pinene: This terpene normalizes stomach acid levels by interacting with the digestive system. It provides anti-inflammatory effects in the gut and calms digestive distress. Pinene also acts on the brain's CB1 receptors to reduce nausea signaling. Pinene may support nausea relief indirectly by improving overall respiratory comfort and reducing stress.
4. Myrcene: This common terpene relaxes smooth muscle tissue in the digestive tract to ease cramping. It reduces inflammation through multiple pathways in the gut and brain. Myrcene also helps regulate normal digestive motility and function. Bathula and Maciver showed that a balanced THC and CBD extract rich in myrcene reduced chemotherapy-induced nausea and vomiting in gynecologic cancer patients.
5. Linalool: This floral terpene blocks 5-HT3 receptors to directly reduce nausea signaling in the brain. It regulates serotonin levels which affect mood and digestive function. Linalool also reduces anxiety which worsens nausea symptoms.
6. Terpinolene: This terpene provides gentle stomach-settling effects, particularly when combined with other terpenes. Tomko, et. al. explain that terpinolene is often found in essential oils with anti-inflammatory and antioxidant properties that soothe gastrointestinal irritation. 

Experience the soothing power of our Bliss edibles, featuring these fragrant, nausea-relieving compounds. Our delicious melon gummies contain 5 mg of calming CBD and 5 mg of THC for a gentle, natural way to ease discomfort and promote relaxation. 

What are the best terpenes to soothe stomach pain?

Physical discomfort from stomach pain can trigger nausea through nerve signals in the gut-brain axis. At the same time, prolonged nausea can cause stomach muscle tension, cramping, and inflammation. Both conditions feed off each other: severe stomach pain sends distress signals to the brain's nausea center, while the muscle tension from constant nausea causes abdominal pain.

Here are the main terpenes found in cannabis that target pain and inflammation in the stomach:

• Humulene reduces gastrointestinal inflammation by blocking inflammatory cytokine production. Becker and Holtmann found that this terpene blocks the release of IL-6, a key inflammatory cytokine that triggers pain and discomfort in the digestive system. Humulene also regulates smooth muscle contractions in the digestive tract to relieve cramping pain.
• Pinene acts directly on pain receptors in the gut while decreasing inflammation in the GI tract. It’s particularly effective against inflammatory bowel conditions and chronic stomach pain.
• Caryophyllene is a potent anti-inflammatory that activates CB2 receptors throughout the digestive system to reduce pain and swelling. This terpene crosses the blood-brain barrier to provide full-body relief.
• Eucalyptol helps with sharp, cramp-like stomach pain. Research shows that this terpene blocks leukotrienes that cause gastric injury, while also relaxing smooth muscle contractions in the digestive tract.
• Bisabolol calms irritated stomach tissue and helps normalize digestive motility that causes painful cramping. A 2022 study reveals that bisabolol fights gut inflammation by activating PPAR-gamma receptors in the colon, which decreases inflammatory cytokines and pain signals in the stomach.

Explore our collection of hybrid cannabis edibles that feature balanced blends of cannabinoids and terpenes for relaxation, pain and inflammation relief, and a boost of wellness.

What terpenes are the best to stimulate appetite?

Prolonged nausea can severely impact your appetite and quickly lead you into a troubling cycle where lack of nutrition worsens nausea and overall health. When feeling nauseated, the thought of food often triggers more discomfort, which is why many people avoid eating altogether. This can result in nutrient deficiencies, dehydration, fatigue, and weakened immunity—all of which intensify nausea symptoms. 

Cannabis is well-known for stimulating appetite, but its effectiveness goes beyond the benefits of THC and CBD The following ten terpenes work alongside cannabinoids to naturally regulate appetite and digestion.

1. Limonene
2. Valencene
3. Ocimene
4. Terpineol
5. Geraniol
6. Beta-caryophyllene
7. Phellandrene
8. Borneol
9. Sabinene
10. Alpha-terpinene

The best cannabis strains for nausea relief

Certain cannabis strains combine specific ratios of therapeutic compounds that work together for maximum nausea relief. Through decades of selective breeding, certain hybrids have emerged as particularly potent at calming the mind and stomach through their unique profiles of cannabinoids and terpenes. 

Sativa strains can increase anxiety and worsen nausea for some people, while pure indicas may cause excessive sedation that can make nausea feel worse. Hybrid strains offer the best of both worlds by combining the focused clarity of sativas with the physical relaxation of indicas. Their balanced effects calm nausea while keeping you functional.

Here are the top six hybrid strains for nausea relief:

1. Blue Dream
2. Girl Scout Cookies
3. OG Kush
4. Wedding Cake
5. Zkittlez
6. Gelato

With nama™,you can enjoy the perfect combination of hybrid strains that provide nausea relief throughout your day. Our thoughtfully balanced products harness the powerful anti-nausea properties of multiple strains in gentle microdoses of 2–10 mg of THC, allowing you to feel better while staying clear-headed and at ease.

Order the best hybrid gummies for nausea relief

Our company is dedicated to crafting premium cannabis products that soothe and support your well-being. Our hybrid THC gummies and cannabis-infused beverages are formulated with nature’s most effective nausea-relieving terpenes to provide gentle, natural relief.

Each product features carefully balanced blends of cannabinoids and terpenes, including calming myrcene, refreshing limonene, and anti-inflammatory beta-caryophyllene. Paired with precise ratios of CBD and THC, these blends target nausea while keeping you clear-headed and at ease.

We source only the highest-quality, hemp-derived extracts, and every product undergoes rigorous testing for purity and potency. Plus, all our edibles are federally legal in the U.S.

With nama™, you’re not just choosing cannabis—you’re embracing a thoughtfully curated experience. Order our products today and discover how these therapeutic terpene profiles can help you find lasting relief from nausea.

Resources

Araruna, M. E., Serafim, C., Júnior, E. A., Hiruma-Lima, C., Diniz, M., & Batista, L. (2020). Intestinal Anti-Inflammatory Activity of Terpenes in Experimental Models (2010–2020): A Review. Molecules, 25(22), 5430. https://doi.org/10.3390/molecules25225430

Parker, L. A., Rock, E. M., & Limebeer, C. L. (2011). Regulation of nausea and vomiting by cannabinoids. British Journal of Pharmacology, 163(7), 1411. https://doi.org/10.1111/j.1476-5381.2010.01176.x

Swenson, K. (2023). Cannabis for morning sickness: areas for intervention to decrease cannabis consumption during pregnancy. Journal of Cannabis Research, 5(1). https://doi.org/10.1186/s42238-023-00184-x

Clunas, H., & Jimenez Naranjo, C. (2021). A Review of the Potential Use of Pinene and Linalool as Terpene-Based Medicines for Brain Health: Discovering Novel Therapeutics in the Flavours and Fragrances of Cannabis. Frontiers in Psychiatry, 12, 583211. https://doi.org/10.3389/fpsyt.2021.583211

Bathula, P. P., & Maciver, M. B. (2023). Cannabinoids in Treating Chemotherapy-Induced Nausea and Vomiting, Cancer-Associated Pain, and Tumor Growth. International Journal of Molecular Sciences, 25(1), 74. https://doi.org/10.3390/ijms25010074

Tomko, A. M., Whynot, E. G., Ellis, L. D., & Dupré, D. J. (2020). Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis. Cancers, 12(7), 1985. https://doi.org/10.3390/cancers12071985

Becker, L., & Holtmann, D. (2024). Anti-inflammatory effects of α-humulene on the release of pro-inflammatory cytokines in lipopolysaccharide-induced THP-1 cells. Cell Biochemistry and Biophysics, 82(2), 839–847. https://doi.org/10.1007/s12013-024-01235-7

Shiekh, R. a. E., Atwa, A. M., Elgindy, A. M., Mustafa, A. M., Senna, M. M., Alkabbani, M. A., & Ibrahim, K. M. (2024). Therapeutic applications of eucalyptus essential oils. Inflammopharmacology. https://doi.org/10.1007/s10787-024-01588-8

Venkataraman, B., Almarzooqi, S., Raj, V., Dudeja, P. K., Bhongade, B. A., Patil, R. B., Ojha, S. K., Attoub, S., Adrian, T. E., & Subramanya, S. B. (2022). α-Bisabolol Mitigates Colon Inflammation by Stimulating Colon PPAR-γ Transcription Factor: In Vivo and In Vitro Study. PPAR Research, 2022, 5498115. https://doi.org/10.1155/2022/5498115

Further reading

The best type of hybrid weed for nausea

Indica vs sativa vs hybrid cannabis strains

Is hybrid weed an upper or downer?

Sativa or hybrid strains for pain relief

Does hybrid weed have side effects?

Is 10 mg of THC too much?

Which terpenes boost energy?

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