What is caryophyllene?

Caryophyllene is a cannabis terpene known for its spicy, peppery aroma and ability to reduce inflammation. Hybrid cannabis strains are the best way to experience the balanced effects of cannabinoids and terpenes. Hybrids combine the benefits of both indica and sativa for a more rounded experience.

Enjoy the benefits and the delicious flavors of our low-dose THC gummies. These microdosed treats combine the best effects of indica and sativa with a full spectrum of terpenes and cannabinoids for an experience that hits just right.

What are the effects of caryophyllene?

Caryophyllene resides in cannabis, black pepper, cloves, and many other spices. Chemically, it is a sesquiterpene, meaning it has three isoprene units. Its chemical formula is C15H24, and it is classified as a bicyclic compound. This structure allows it to interact with different receptors in the body. 

Beta-caryophyllene is the most prominent form of caryophyllene. It is unique among terpenes because it acts as a cannabinoid and directly interacts with the body's endocannabinoid system (ECS), specifically the CB2 receptors. These receptors are responsible for regulating inflammation, pain, and immune response. 

Unlike tetrahydrocannabinol (THC), which binds to CB1 receptors and creates a psychoactive effect, caryophyllene doesn't get you "high." Its interaction with CB2 receptors produces anti-inflammatory, analgesic (pain-relieving), and neuroprotective properties. That’s why caryophyllene might be a great option for handling arthritis, chronic pain, and even anxiety.

Here’s how caryophyllene affects you:

• Reduces stress and promotes calm without causing drowsiness
• Eases muscle and joint pain
• Relieves muscle tension
• Lowers inflammation
• Delivers clear-headed relief without psychoactive effects
• Stabilizes mood and effectively reduces anxiety and stress

While not as abundant as limonene or myrcene, caryophyllene contributes to the scent of many cannabis strains and their therapeutic effects. This combination of aromatic compounds enhances the entourage effect, where different elements work together for greater impact.

Caryophyllene’s balanced effects fit with the growing trend of microdosing cannabis. Microdosing involves consuming small amounts of Delta 9 THC and cannabidiol (CBD) which deliver powerful benefits without overwhelming effects.

Read more about the benefits of microdosing cannabis and how small amounts of cannabinoids and caryophyllene-rich terpenes can boost your overall health.

What are the benefits of caryophyllene?

Caryophyllene provides a range of valuable benefits. Italian researchers found that, through the binding to CB2 cannabinoid receptors, beta-caryophyllene “shows beneficial effects on obesity, non-alcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH) liver diseases, diabetes, cardiovascular diseases, pain, and other nervous system disorders.”

Here’s a look at how it can positively impact your body:

• Caryophyllene reduces inflammation in the body. This makes it useful for managing chronic inflammatory conditions such as arthritis, inflammatory bowel disease, and other autoimmune disorders.
• It offers natural pain relief by targeting muscle and joint discomfort. This eases chronic pain in conditions such as fibromyalgia or muscle soreness.
• Caryophyllene's calming effects lower stress and anxiety levels. Unlike some other terpenes or cannabinoids, it does this without making you feel overly sedated. According to a 2020 study, caryophyllene reduces stress-induced behaviors and improves neuroinflammatory and neurotrophic responses. Through the endocannabinoid system, it stabilizes and balances your mood.
• Emerging research suggests that caryophyllene may protect the brain and nervous system and slow the progression of neurodegenerative diseases such as Alzheimer's or Parkinson's disease.
• Caryophyllene acts as an antioxidant and neutralizes free radicals in the body. This reduces oxidative stress and lowers the risk of cancer and cardiovascular conditions. Read more about the antioxidant properties of cannabis.
• Its anti-inflammatory effects may extend to the digestive system and alleviate symptoms of irritable bowel syndrome (IBS) or Crohn's disease.
• Caryophyllene has shown antimicrobial properties. It combats infections and improves immune response.
• Applied topically, caryophyllene reduces skin inflammation and improves eczema or acne.

Participating in the entourage effect, caryophyllene works together with other cannabinoids and terpenes to enhance the therapeutic power of cannabis beyond its scent and taste.

Try our Relax Plus gummies with only 5 mg of THC, 25 mg of CBD, and a terpene-rich profile featuring caryophyllene and other soothing terpenes. This balanced blend amplifies the entourage effect and delivers more complete benefits than THC or CBD on their own.

“These gummies taste great and are wonderful after a hard day at work. They help you unwind and leave your stress behind…”

—Tammy M.

The flavor profile of caryophyllene

Caryophyllene has a bold, spicy flavor profile. It’s peppery and earthy, similar to black pepper or cloves. Its taste carries a warm, slightly sharp bite, adding depth to its flavor experience. 

The smell is equally striking, with rich, woody undertones that complement its spicy nature. This unique combination of flavors and aromas makes caryophyllene a standout terpene in cannabis and other plants, contributing a distinct, robust character.

Caryophyllene's bold flavors pair nicely with our microdosed cannabis gummies. Enjoy a balanced, flavorful experience that combines the natural benefits of cannabis with mouthwatering fruit infusions.

Does caryophyllene have side effects?

Caryophyllene is safe when used in typical amounts found in foods, essential oils, or cannabis products. Like many compounds, excessive use or exposure may lead to potential side effects:

• Dry mouth
• Mild dizziness
• Interaction with medications
• Gastrointestinal discomfort
• Allergic reactions

These side effects are linked to unusually high exposure levels, far exceeding what you’d typically encounter with regular use of caryophyllene-containing products—especially our microdosed edibles.

What strains are rich in caryophyllene?

Caryophyllene more commonly appears in indica strains, known for their relaxing and soothing properties. While indica varieties are rich in it, hybrid strains are a much better choice if you're looking for a more balanced and soothing experience. 

Here are six strains rich in caryophyllene:

1. Girl Scout Cookies: A popular hybrid known for its potent effects and high caryophyllene content, Girl Scout Cookies offer a strong, earthy flavor with sweet undertones.
2. Sour Diesel: This sativa-dominant strain is loved for its energizing effects, is packed with caryophyllene, and gives it a distinct spicy and fuel-like aroma.
3. Bubba Kush: A classic indica strain, Bubba Kush is rich in caryophyllene and it provides a peppery flavor and a calming, sedative effect.
4. Chemdawg: Known for its powerful, pungent scent, Chemdawg features high levels of caryophyllene that enhance its potent, relaxing effects.
5. OG Kush: This hybrid has a balanced, earthy flavor. OG Kush is high in caryophyllene, so it’s great for stress relief and reducing anxiety.
6. Purple Punch: This indica-dominant strain combines sweet, fruity flavors with caryophyllene’s spicy profile, known for its calming and relaxing properties.

With nama™ gummies and THC-infused drinks, you don’t have to choose between strains. Our microdosed cannabis products balance CBD and THC (10 mg of THC per serving or less) while preserving rich terpene profiles. These drinks keep you clear-headed and functional throughout the day.

Infuse your favorite mocktails with our Buzz Drops™ and create delicious buzztails™ for a sophisticated, enjoyable way to experience cannabis. They’re perfect for social gatherings or a relaxing evening at home. 

Looking for a creative twist? Try adding a few drops of our liquid cannabis tincture to the virgin Bloody Mary or give a caryophyllene-rich take on a classic Tom Collins. These healthier alcohol alternatives might just be your new cozy-night favorite.

Order balanced hybrid gummies and drinks

Looking for hybrid cannabis products rich in beneficial terpenes such as bisabolol, limonene, and camphene? We've got you covered. We've crafted unique recipes that combine calming terpenes, with a focus on caryophyllene for its potential anti-inflammatory and stress-relieving properties. 

Our products use high-quality, hemp-derived extracts for a consistent and effective experience every time. Whether you're seeking relief from stress or better sleep, our terpene-rich formulations help you unwind and find balance.

With our microdosed products, you're in control of your cannabis experience. Our gummies and drinks are federally legal and rigorously tested. So go ahead, explore the world of aromatic terpenes and therapeutic cannabinoids, and buy your Delta 9 gummies from nama.

Resources

Scandiffio, R., Geddo, F., Cottone, E., Querio, G., Antoniotti, S., Gallo, M. P., Maffei, M. E., & Bovolin, P. (2020). Protective Effects of (E)-β-Caryophyllene (BCP) in Chronic Inflammation. Nutrients, 12(11). https://doi.org/10.3390/nu12113273

Hwang ES, Kim HB, Lee S, Kim MJ, Kim KJ, Han G, Han SY, Lee EA, Yoon JH, Kim DO, Maeng S, Park JH. Antidepressant-like effects of β-caryophyllene on restraint plus stress-induced depression. Behav Brain Res. 2020 Feb 17;380:112439. doi: 10.1016/j.bbr.2019.112439. Epub 2019 Dec 17. PMID: 31862467.

Viveros-Paredes, J. M., González-Castañeda, R. E., Gertsch, J., Chaparro-Huerta, V., López-Roa, R. I., Vázquez-Valls, E., Beas-Zarate, C., Camins-Espuny, A., & Flores-Soto, M. E. (2017). Neuroprotective Effects of β-Caryophyllene against Dopaminergic Neuron Injury in a Murine Model of Parkinson’s Disease Induced by MPTP. Pharmaceuticals, 10(3). https://doi.org/10.3390/ph10030060

Further reading

The best sleep gummies for adults

Will a hybrid strain get me high?

Best terpenes for promoting sleep

Can you get a headache from edibles?

How to make delicious THC drinks

Can microdosing alleviate my PTSD?

Is hybrid or sativa better for sleep?

Is a 10 mg edible too strong for beginners?

Hybrid cannabis strains for relaxation

nama CBD FDA & legal disclaimer

Our products are not intended to diagnose, treat, cure, or prevent any disease. They are not a replacement for prescription medications and have not been evaluated by the U.S. Food and Drug Administration (FDA).

The information provided on this website does not and is not intended to, constitute legal advice or any statement of the status of any laws. Any information, content, and materials available on this site are for general informational purposes only and are not intended to be relied upon for any purpose.

Readers of this website should contact their attorney to obtain advice with respect to any particular legal matter, including decisions on what products are, or are not, legal to sell, possess, or consume. No reader, user, or browser of this site should act or refrain from acting on the basis of the information on this site without first seeking legal advice from their own counsel in the relevant jurisdiction.